产品货号：
Z19281
中文名称：
KCTD11抗体
英文名称：
Anti-KCTD11 Antibody (N-Term)
产品规格：
50μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-KCTD11 Antibody (N-Term) |
| 指标别名 | BTB/POZ domain-containing protein KCTD11;KCTD11;C17orf36;REN |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | WB,IHC |
| 基因名称 | KCTD11 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | This KCTD11 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 21-53 amino acids from human KCTD11. |
| 计算分子量 | 26kDa |
| 成分 | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein A column,followed by peptide affinity purification |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Plays a role as a marker and a regulator of neuronal differentiation;Up-regulated by a variety of neurogenic signals,such as retinoic acid,epidermal growth factor/EGF and NGFB/nerve growth factor.Induces apoptosis,growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B.Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB).Acts as an E3 ubiquitin-protein ligase towards HDAC1,leading to its proteasomal degradation.Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1,thus maintaining cerebellar granule cells in undifferentiated state,this effect probably occurs via HDAC1 down-regulation,keeping GLI1 acetylated and inactive.When knock- down,Hedgehog antagonism is impaired and proliferation of granule cells is sustained.Activates the caspase cascade. |
| Uniprot ID | Q693B1 |
| 推荐稀释比 | WB~~1:1000～1:2000 IHC~~1:25 |
相关搜索：KCTD11抗体，KCTD11(N-Term)多抗，Anti-KCTD11 Antibody (N-Term)